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Joseph E Saavedra Selected Research

O(2)- (2,4- dinitro- 5- (N- methyl- N- 4- carboxyphenylamino)phenyl 1- N,N- dimethylamino)diazen- 1- ium- 1,2- diolate

8/2015PABA/NO lead optimization: Improved targeting of cytotoxicity to glutathione S-transferase P1-overexpressing cancer cells.
3/2012Growth-inhibitory and chemosensitizing effects of the glutathione-S-transferase-π-activated nitric oxide donor PABA/NO in malignant gliomas.
12/2008Aryl bis(diazeniumdiolates): potent inducers of S-glutathionylation of cellular proteins and their in vitro antiproliferative activities.
3/2008Synthesis, nitric oxide release, and anti-leukemic activity of glutathione-activated nitric oxide prodrugs: Structural analogues of PABA/NO, an anti-cancer lead compound.
1/2008Structure-Based Design of Anticancer Prodrug PABA/NO.
2/2006PABA/NO as an anticancer lead: analogue synthesis, structure revision, solution chemistry, reactivity toward glutathione, and in vitro activity.
5/2004Tumor cell responses to a novel glutathione S-transferase-activated nitric oxide-releasing prodrug.

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Joseph E Saavedra Research Topics

Disease

31Neoplasms (Cancer)
08/2017 - 10/2003
6Glioma (Gliomas)
06/2017 - 10/2003
6Hyperplasia
05/2011 - 01/2008
6Leukemia
12/2010 - 04/2003
4Carotid Artery Injuries
05/2011 - 01/2008
4Breast Neoplasms (Breast Cancer)
04/2011 - 10/2004
4Myeloid Leukemia (Leukemia, Myelocytic)
11/2009 - 04/2003
4Inflammation (Inflammations)
01/2008 - 07/2004
3Hepatocellular Carcinoma (Hepatoma)
08/2017 - 12/2003
3Glioblastoma (Glioblastoma Multiforme)
06/2017 - 01/2016
3Heart Failure
11/2010 - 12/2005
2Necrosis
01/2016 - 08/2003
2Fatty Liver
07/2015 - 02/2015
2Brain Neoplasms (Brain Tumor)
04/2013 - 10/2003
2Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
11/2011 - 02/2011
2Acute Myeloid Leukemia (Acute Myelogenous Leukemia)
10/2006 - 04/2003
2Ovarian Neoplasms (Ovarian Cancer)
02/2006 - 05/2004
1Infections
08/2017
1Ataxia Telangiectasia (Louis Bar Syndrome)
08/2017
1Non-alcoholic Fatty Liver Disease
07/2015
1Insulin Resistance
02/2015
1Acute Erythroblastic Leukemia (Erythroleukemia)
03/2014
1Adenocarcinoma of Lung
02/2011
1Lung Neoplasms (Lung Cancer)
02/2011
1Central Nervous System Neoplasms
02/2011
1Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia)
12/2010
1Type 1 Diabetes Mellitus (Autoimmune Diabetes)
09/2010
1Vascular System Injuries
05/2010

Drug/Important Bio-Agent (IBA)

33Nitric Oxide (Nitrogen Monoxide)FDA Link
08/2017 - 04/2003
26ProdrugsIBA
08/2017 - 04/2003
15Glutathione (Reduced Glutathione)IBA
06/2017 - 04/2003
8diazeniumdiolateIBA
03/2014 - 12/2003
7Proteins (Proteins, Gene)FDA Link
08/2017 - 07/2005
7TransferasesIBA
06/2017 - 06/2004
7O(2)- (2,4- dinitro- 5- (N- methyl- N- 4- carboxyphenylamino)phenyl 1- N,N- dimethylamino)diazen- 1- ium- 1,2- diolateIBA
08/2015 - 05/2004
6Glutathione Transferase (Glutathione S-Transferase)IBA
08/2015 - 05/2004
6Biological ProductsIBA
04/2013 - 10/2004
6proline-nitric oxideIBA
02/2011 - 10/2003
5Nitric Oxide DonorsIBA
06/2017 - 10/2003
5EnzymesIBA
08/2015 - 05/2004
5O(2)- vinyl- 1- (pyrrolidin- 1- yl)diazen- 1- ium- 1,2- diolateIBA
07/2015 - 08/2003
5O-(glucuronic acid 2-sulfate)-(1--3)-O-(2,5)-andydrotalitol 6-sulfateIBA
04/2013 - 06/2004
4Pharmaceutical PreparationsIBA
08/2015 - 05/2004
3AcidsIBA
07/2015 - 10/2003
3ArsenicIBA
08/2011 - 06/2004
3Cisplatin (Platino)FDA LinkGeneric
01/2008 - 06/2004
2DNA (Deoxyribonucleic Acid)IBA
08/2017 - 07/2007
2Poly(ADP-ribose) Polymerases (Poly ADP Ribose Polymerase)IBA
08/2017 - 03/2014
2Fatty Acids (Saturated Fatty Acids)IBA
07/2015 - 02/2015
2Glucose (Dextrose)FDA LinkGeneric
07/2015 - 02/2015
2CaspasesIBA
03/2014 - 10/2006
2Carboplatin (JM8)FDA LinkGeneric
03/2012 - 10/2003
2Sucrose (Saccharose)IBA
02/2011 - 10/2003
2Reactive Oxygen Species (Oxygen Radicals)IBA
02/2011 - 12/2008
2Cytochromes c (Cytochrome c)IBA
02/2011 - 10/2006
2nitroxylIBA
05/2010 - 12/2005
2Estrogens (Estrogen)FDA Link
10/2005 - 10/2004
1Checkpoint Kinase 1IBA
08/2017
1Caspase 3 (Caspase-3)IBA
08/2017
1Checkpoint Kinase 2IBA
08/2017
1Caspase 7IBA
08/2017
1Matrix Metalloproteinases (MMPs)IBA
01/2017
1O2-vinyl 1- (2- (carboxylato)pyrrolidin- 1- yl)diazen- 1- ium- 1,2- diolateIBA
07/2015
1Triglycerides (Triacylglycerol)IBA
02/2015
1DiglyceridesIBA
02/2015
1CeramidesIBA
02/2015
1Metformin (Glucophage)FDA LinkGeneric
02/2015
1CholesterolIBA
02/2015
1Temozolomide (Temodar)FDA LinkGeneric
03/2012
1thiazolyl blueIBA
03/2012
12- cyclohexylidenhydrazo- 4- phenyl- thiazoleIBA
03/2012
1Antineoplastic Agents (Antineoplastics)IBA
02/2012
1Messenger RNA (mRNA)IBA
02/2012
1Hormones (Hormone)IBA
05/2011
1Guanosine Monophosphate (5' Guanylic Acid)IBA
02/2011
1Cytotoxins (Cytolysins)IBA
02/2011
1Dexamethasone (Maxidex)FDA LinkGeneric
02/2011
1Guanylate Cyclase (Guanylyl Cyclase)IBA
02/2011
1Indomethacin (Indometacin)FDA LinkGeneric
02/2011
1Phosphodiesterase InhibitorsIBA
02/2011
16-anilino-5,8-quinolinedioneIBA
02/2011
1Prostaglandin-Endoperoxide Synthases (Cyclooxygenase)IBA
02/2011
18-bromoguanosineIBA
02/2011
1Biomarkers (Surrogate Marker)IBA
02/2011
1Nitric Oxide Synthase (NO Synthase)IBA
02/2011
1zaprinastIBA
02/2011
1iodoantipyrineIBA
02/2011
1pimagedine (aminoguanidine)IBA
02/2011
1Reactive Nitrogen SpeciesIBA
02/2011
1CateninsIBA
12/2010
1Insulin (Novolin)FDA Link
09/2010
1Streptozocin (Streptozotocin)FDA Link
09/2010
1Vasodilator Agents (Vasodilators)IBA
05/2010
11-isopropyldiazen-1-ium-1,2-diolateIBA
05/2010
1Etoposide (VP 16)FDA LinkGeneric
11/2009
1Daunorubicin (Cerubidine)FDA LinkGeneric
11/2009

Therapy/Procedure

13Therapeutics
01/2016 - 01/2008
3Drug Therapy (Chemotherapy)
02/2011 - 10/2003
1Radiotherapy
06/2017
1Aftercare (After-Treatment)
01/2016